الفهرس 
Change in total testosterone hormone in patients with polycystic ovary syndrome after laparoscopic ovarian drilling
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Abstract
To evaluate the role of laparoscopic ovarian drilling (LOD) in changing
the level of total testosterone hormone in patients with polycystic ovary syndrome
(PCOS).
Methods: It was performed by measurement of Serum level of total testosterone
before and after 3 months of Laparoscopic ovarian drilling And also the
decrease of serum level of total testosterone and the effect on ovarian reserve by
measuring serum FSH after 3 months of Laparoscopic ovarian drilling in 40
infertile patients with PCOS resistant to induction by CC for 6 consecutive cycles,
all patients were hyper androgenic before LOD.
Forty patients from about seventy five patients were evaluated and
diagnosed to have PCOS and by history, physical examination and investigations,
and after getting the approval of ethical committee and took their consent .
All patients were subjected for measurement of Serum level of:
Total testosterone hormone and FSH before and after LOD, blood samples were
taken from each patient were named sample A and B
Sample A: was taken before LOD.
Sample B: was taken 3 months after LOD.
Timing of LOD: 2-3 days after the end of menstrual bleeding LOD was
performed using diathermy probe pressed against the ovarian antimesentric surface
performing 4-6 punctures on each ovary 4-5 mm apart through the ovarian cortex
to a depth of 4-5 mm graduated on specific needle used for the procedure using coagulation current of 40 w . Then the ovaries were immediately cooled by raining
with normal saline solution.
Results: The total testosterone hormone was decreased after drilling with
statistically highly significant difference in comparison to the level before .
FSH was increased after drilling with statistically highly significant
difference in comparison to the level before
Conclusion: The laparoscopic ovarian drilling reduces the Total Testosterone
Hormone level in patients with PCOS within 3 months of the procedure , which
may fortify the chances of success of a subsequent induction of ovulation
especially among clomiphene citrate resistant patients.