الفهرس 
Introduction and aim of the workOnly 14 pages are availabe for public view
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Abstract
The heart is a vital organ in human body. The heart is exposed to numerous forms of injury. Doxorubicin (DOXO) is one of the anthracycline antibiotics that is clinically used as a chemotherapeutic drug for many types of solid tumors. It gives rise to cardiotoxicity (cardiomyopathy). Amino acids, such as glycine, have a great importance in heart diseases treatment.
The aim of this study was to investigate the possible cardioprotective effect of glycine in DOXO-induced cardiotoxicity model in male albino mice and to prospect the underlying mode of action as well.
To achieve our goals, fifty male mice were divided into five groups of ten animals each as follows: Control group: contains normal mice. DOXO (cardiomyopathy; cardiac toxicity) group: mice received DOXO (i.p.)for a cumulative dose of 15 mg/kg for 10 days. Gp100 group: concomitant with DOXO, mice received glycine once a day (i.p., 100 mg/kg/day) for 10 days. Gp150 group: concomitant with DOXO, mice received glycine once a day (i.p., 150 mg/kg/day) for 10 days. Gp200 group: concomitant with DOXO, male mice received glycine once a day (i.p., 200 mg/kg/day) for 10 days.
In conclusion, our study results show that glycine has good antioxidant and therapeutic properties, which can help in treating and preventing DOXO-induced cardiotoxicity.