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Abstract
Juvenile idiopathic arthritis is the most common pediatric rheumatic disease with significant long-term morbidity and mortality. Both innate and adaptive immunity are involved in the pathogenesis. Measuring the level of both atypical CD14+CD16+ peripheral monocytes subset and typical subset CD14++CD16- in patients during activity and remission showed no significant different for the atypical subset and a significant increase in the typical subset during disease activity especially in the systemic onset juvenile idiopathic arthritis