الفهرس Only 14 pages are availabe for public view
 |  | from | 271 |  |  |
| | | from | 271 | | |
Abstract
Vancomycin hydrochloride is a glycopeptide antibiotic with a relatively high molecular weight of 1485.7 Da, used in the prophylaxis and treatment of infections caused by gram-positive bacteria. However ototoxicity and nephrotoxicity is seen to be associated with vancomycin administration, in addition to thrombophlebitis and infusion related reaction known as red man syndrome. Therefore designing a delivery system capable of providing sustained serum level of vancomycin hydrochloride above MIC of target pathogen for prolonged duration is a desirable target. Several attempts have been done in order to formulate and design a delivery system able to provide sustained vancomycin serum level such as biodegradable in situ gel-forming controlled drug delivery, biodegradable chitosan microspheres and scaffolds. Also several researchers noted that vancomycin encapsulation into liposomal or nano sized vehicle offered an enhancement in pharmacodynamics, pharmacokinetics characteristics of drug and decreased its toxicity compared to standard preparations