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Abstract
The present study was designed to evaluate the anti-androgenic effect of some plants in castrated rats (flaxseed, sesame seeds, safflower seeds and soybean seeds) which were analyzed then petroleum ether and ethanol extracts were prepared from these samples. Some phytochemicals such as total phenolic compounds content, fatty acids, hydrocarbons and phytosterols contents were determined in all the studied plants. Also the anti - cancer effect of all the plants powder under investigation were studied against prostate cancer using cell-line technique. In the first experiment of the present study flax, sesame, safflower and soybean seeds were evaluated as anti-androgenic agents in castrated/testosterone rats in form of petroleum ether, ethanol extracts and whole powder. The nutritional safety of these studied plants and their extracts were evaluated through kidneys and liver functions. In the second experiment of this study, the most efficient treatments of the first experiment were studied in animal model of benign prostate hyperplasia (BPH) to evaluate the anti-androgenic effect of the plants under study in an animal model of BPH