الفهرس Only 14 pages are availabe for public view
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Abstract
The laryngeal carcinoma is the second most common head and neck squamous cell carcinoma. Cell cycle progression is facilitated by CDKs that are activated by cyclins, including Cyclin D1. Evidence of the involvement of Cyclin gene alterations and overexpression of various cyclins in human cancer is growing. The role of Cyclin D1 in malignant progression of laryngeal squamous cell carcinoma (LSCC) has yet to be established. Cyclin D1 protein was studied in 40 LSCC patients including 20 cases of Grade II, 9 cases of Grade I , 9 cases of Grade III and two cases of carcinoma insitu, retrieved as routinely processed paraffin blocks taken from the department of Pathology, Kasr El-Ainy Hospital. For all specimens, some clinical data were available on the computer files including age and sex of the patients, tumor site, tumor grading, tumor staging, infiltration of underlying cartilage and lymph node metastasis. Using Immunohistochemistry, Cyclin D1 Expressors were considered in cases exhibiting moderate or intense positive nuclear staining in {u2265} 10 of tumor cells. 23 patients (57.5 %) were considered Cyclin D1 expressors and 17 patients (42.5 %) were considered non-expressors. A significant relation was detected between Cyclin D1 expression on one hand and tumor grading, infiltration of thyroid cartilage and keratinization on one the other hand.