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Abstract
from this study we can conclude that locally produced growth factor, such as VEGF has significant important modulatory role in follicular growth and development by angiogenesis. Our study demonstrated that VEGF concentration in FF is positively correlated with follicular diameter and volume of FF r - 0.885 (p - value 0.0001). HS VEGF is the major regulator of ovarian angiogenesis and may play a modulator role in the functional activity of GCs and follicular growth. Local production of VEGF may be important for mediating the GC - theca cell interaction required for antral follicle development. VEGF is associated with higher fertilization rate of mature oocytes. oocytes with positive fertilization had higher VEGF concentration (357.7 ± 176.1) than negative fertilized oocytes 351.8 ± 229.2 p - value, 918 NS