الفهرس 
IntroductionOnly 14 pages are availabe for public view
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Abstract
Background and objective: Glutathione can alter the depigmentation of skin and convert eumelanin to pheomelanin during melanogenesis. As a result, glutathione has become one of the most used skin-whitening agents, and women have become obsessed with it. So, the purpose of this study was to see how intramuscular glutathione injection can affect the ovaries of female albino rats as well as pancreas because of diabetes widespread.
Methods: 80 female albino rats were involved in this study. The animals were divided into two groups; A: the control group and B: the glutathione-injected group, which received glutathione intramuscularly three times per week for three consecutive weeks at a dose of 186 mg/ kg/ day. The injected group was subdivided into four subgroups based on how soon after the last dose the rats were sacrificed (B1: immediately, B2: after 24h, B3: after one week and B4: after two weeks). Ovarian and pancreatic tissue samples were collected from all groups. Each sample was subjected for histopathological examination and estimation of estrogen and progesterone in ovaries, glucose, insulin and lipase in pancreas by ELISA. Malondialdehyde (MDA) and reduced glutathione (GSH) also were detected.
Results: MDA level was significantly higher in subgroups of group B than group A, while GSH level was significantly reduced. The histopathological examination revealed that glutathione injections led to edematous stroma and luteoma in ovaries samples, while in pancreas samples, there were inflammation, atypical cells and vessels congestion. As regard ovarian hormones levels, there was significant increase in all (B) subgroups compared to control group. Regards pancreas biochemical study, there were increase in glucose level while there was decrease in insulin and lipase levels. In this study, changes caused by the prooxidant behavior of glutathione, were reduced partially after two weeks.