الفهرس 
Impact Of Tranexamic Acid On Reducing Blood Loss In Pregnant Women On Parentral Anticoagulant Undergoing Cesarean Section : b) A Randomized Controlled Study
AbstractOnly 14 pages are availabe for public view
 |  | from | 116 |  |  |
| | | from | 116 | | |
Abstract
Background: Cesarean section is the most common major surgery world wide and almost one third of women have blood loss that exceed 1000 ml. There are so many reason for which pregnant females are receiving parenteral anticoagulation including prior deep vein thrombosis (DVT), pulmonary embolism (PE), cerebrovascular accident (CVA), atrial fibrillation, mechanical heart valves, or prothrombotic condition (Factor V Leiden deficiency, protein C deficiency, antiphospholipid syndrome).
Tranexamic acid (TA) is considered the most commonly used anti-fibrinolytic agent being very easily available and cheap.
Objective: The purpose of this study is to evaluate the effect of Tranexamic acid in reducing blood loss without inducing unfavorable thromboembolic events in patients undergoing C.S receiving parentral anticoagulants.
Study design:
This randomized controlled study (single blind) compared two groups: (Tranexamic group) included 50 pregnant that received 1gm tranexamic acid (Kapron ® amp, Amoun, Egypt) slow intravenous infusion at the time of skin incision and (Control group) included 50 pregnant that received 10 ml normal saline. Women enrolled in the study was Full-term pregnant female undergoing Cesarean section and receiving parenteral anticoagulation in the form of either low molecular weight heparin (LMWH) or unfractionated heparin (UFH). Our primary outcome is to assess the effect of tranexmic acid in Reduction of blood loss intraoperative and postoperative and Changes in the blood indices in both groups.
Results: Statistical analysis of current results showed that no statistical significant differences between the studied groups regarding demographic characteristics as age, body mass index, parity and gestational age with P> 0.05. Also, operative duration, blood loss, need to utertonics and need to blood transfusion were significantly shorter, lower and less frequent in tranexamic acid group compared with control one. Hemoglobin and hematocrit drops were significantly lower in tranexamic acid group compared with control one.
Conclusion: preoperative administration of 1g of tranexamic acid to the pregnant women undergoing cesarean delivery significantly reduced operative duration, intra and postoperative blood loss, need to utertonics, need to blood transfusion and postoperative DROP of hemoglobin and hematocrit levels with minimal side effects as headache, dizziness, nausea, vomiting, diarrhea and pyrexia.