Search In this Thesis
   Search In this Thesis  
العنوان
Synthesis of Some New Celecoxib Analogues of Expected Anticancer Activity /
المؤلف
Eman Farag Abd El-Halim,
هيئة الاعداد
باحث / Eman Farag Abd El-Halim
مشرف / Omneya Mahmoud Khalil
مشرف / Hala Bakr El-Nassan
مشرف / Asmaa Elsayed Abd El-Latief Kassab
الموضوع
Pharmaceutical Organic Chemistry
تاريخ النشر
2022.
عدد الصفحات
59 p. :
اللغة
الإنجليزية
الدرجة
ماجستير
التخصص
العلوم الصيدلية
تاريخ الإجازة
17/6/2022
مكان الإجازة
جامعة القاهرة - كلية الصيدلة - Pharmaceutical Organic Chemistry
الفهرس
Only 14 pages are availabe for public view

from 70

from 70

Abstract

This thesis comprises four chapters in addition to summaries in English and Arabic;
The first chapter; General introduction which consists of a brief literature review of celecoxib and its analogues, in addition to an account on their cytotoxic activity.
The second chapter; Recent advances in the development of celecoxib analogs as anticancer agents: A review.
The third chapter; Design and synthesis of novel celecoxib analogues with potential cytotoxic and pro-apoptotic activity against breast cancer cell line MCF-7.
The fourth chapter; Design, synthesis, and biological evaluation of new celecoxib analogs as apoptosis inducers and cyclooxygenase‐2 inhibitors