الفهرس 
Introduction and aim of workOnly 14 pages are availabe for public view
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Abstract
Bronchial asthma (asthma) is a common chronic airway disease characterized by variable airflow limitations resulting from the combination of airway narrowing, airway hypersensitivity, airway wall thickening, and increased mucus hypersecretion. Worldwide, the prevalence of asthma has increased significantly. Bronchial asthma is common in Egypt, and children from poor categories are more likely to have undiagnosed or untreated bronchial asthma. In Egypt, asthma prevalence was reported to be 7.7% in children less than 15 years old.
We aimed in this case control study to investigate the genetic polymorphisms of MUC-7, CTLA-4, and CD-28 and their association with bronchial asthma in Egyptian children.
This study was carried out on a total of 200 individuals of Egyptian ethnicity. One hundred (100) asthmatic children aged between 1-18 years (57 girls and 43 boys) and 100 normal healthy controls aged between 6-18 years.
(39 girls and 61 boys). The clinical data of asthmatic patients including age. In conclusion, upon our study findings, we can conclude that the MUC-7*5 allele have a protective role against bronchial asthma among Egyptian children. While CTLA-4+49A/G (rs231775) and CD-28 IVS3 +17T/C (rs3116496) polymorphisms are risk factors for asthma susceptibility in Egyptian children especially in those with atopy status.