الفهرس 
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Abstract
S
UMMARY
eukemia is the most common malignancy affecting children and young adults.
Iron overload in leukemia may occur primarly due to insufficient erythropoiesis or secondary to the nature of disease or due to repeated transfusions.
Red blood cell transfusions are an essential part of supportive care in leukemia treatment ameliorating symptoms of anemia, but there is no physiological mechanism for excretion of excess iron complicating the transfusions.
We conducted this study is to assess the iron overload in pediatric patients with acute leukemia at different treatment phases and at the end of therapy.
The current study assessed 70 patients with AL diagnosed and treated in Pediatric Oncology unit, Ain Shams University.
The patients included in the study were subjected to full history taking, clinical examination, complete blood count, C - reactive protein, liver function assessments and Iron profile.
It was evident among the studied group that there was no significant difference as regards age & sex in relation to serum ferritin and iron profile. Almost 80% of patients had elevated
L
Summary
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ferritin levels with 62.8 % having ferritin levels above 1000 ng/ml.
Serum ferritin varied among different AL groups being significantly higher in patients with T-cell ALL and AML patients.
Serum ferritin levels significantly varied in relation to different treatment stages with significant elevation within early stages of induction and consolidation when compared to continuation phases with tendency to be within normal levels in survivors. Serum ferritin was also higher in patients diagnosed with ALL T cell than ALL pre B and AML patients
In spite of the fact that PRBCs transfusion is one of the main risks for iron over-load in AL patients yet, serum ferritin was not significantly correlated is related to the TTV.
MRI T2*was carried out for selected cases based on their elevated ferritin levels, TTV and age, yet most had normal LIC and no one had severe hepatic iron overload.