الفهرس 
IntroductionOnly 14 pages are availabe for public view
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Abstract
Consumption of milk and milk products is strongly linked to lower postprandial glycemia. Milk proteins, including casein, and whey proteins, have been shown to decrease glucose response while increasing insulin response. However, more research is needed to determine the effect of camel milk and its protein fractions on blood glucose control. The objective of this study was to investigate the acute effect of whole camel milk, micellar casein, and whey proteins on blood glucose and histological changes in vital organs (liver, kidney, pancreas, and spleen in male albino rats. The rationale for this study is based on the fact that milk contains varying concentration and protein structures which may have an effect on diabetic mellites. The hypothesis of this study was that whole, whey proteins and casein of camel milk would have a distinct effect on blood glucose and histological changes in diabetic rats.
In this study Forty -eight pathogen-free adult male albino rats weighing (190±10 g) aged 6-8-week-old were divided into 6 groups, T1 as negative control (normal group; T2 as positive control (diabetic group; T3 diabetic group supplemented with camel milk; T4 diabetic group supplemented with camel milk whey proteins; T5 diabetic group supplemented with Diamicron drug and T6 diabetic group supplemented with camel casein. The results revealed a significant difference (P < 0.05) between diabetic group (T2) and treated groups T3, T4 and T5. However, there was no difference between the treatments T6 and diabetic group. Moreover, T3. T4 and T5 reduced blood glucose with no significant difference when compared to normal group (T1). There was an effect of treatments (T3.T4 and T5 (P < 0.05) on body weight gain but not T6. Liver function (ALT and AST) and kidney function (creatinine) replenished to the normal status at treatment with camel milk, camel whey proteins and drug treated groups but not with casein treated group. Catalase activity, lipid oxidation, alkaline phosphatase and glutathione concentration improved significantly in T3, T4 and T5 groups. The histopathological sections of liver, kidney, spleen, and pancreatic tissues from groups T3, T4 and T5 showed no presence of degeneration, inflammatory cells, and necrosis. The data obtained in this study clearly shows that camel milk and camel milk whey proteins significantly reduced blood glucose level and can be used as adjunctive therapy in type 2 diabetes mellitus.