الفهرس 
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Abstract
In the current thesis, novel hybrid derivatives with potential anticancer activities were designed and synthesized using the 8-hydroxyquinoline scaffold. Hybridization was achieved by 8-hydroxyquinolin pharmacophore amalgamation with well-established anticancer pharmacophores including chalcone, 1,2,4 triazole, 1,2,4 oxadiazole, and hydrazone (Series I-IV, respectively). In addition to the novel fifty-one final hybrids produced, another four new intermediate compounds were formed. Both intermediates and final compounds were In-vitro screened to prove their anticancer activities. selected potentially active hybrids proceeded for molecular mechanistic studies.
This proposal is divided into four major sections: Introduction, aim of the work, results and discussion, and experimental. In addition to the reference section, the abstract and Arabic summary.
1. Introduction.
This section provides an overview of the synthetic processes used for constructing 8-HQ and chalcone and a compendium of their different biological activities, with an emphasis on their anticancer effects. It clarifies the different mechanisms utilized by recent 8-HQ and chalcone derivatives for proceeding with their anticancer actions.
2. Aim of the work.
The objectives behind the intended hybrids’ construction are explained in this section. It also outlines the steps that will be carried out in the present thesis, such as the creation of novel 8-HQ hybrids, the investigation into their biological effects as prospective anticancer candidates, molecular mechanism analysis, molecular docking simulations, and in silico predictions.
3. Results and discussion.
This part provides a detailed explanation of the findings from each step of the desired products’ syntheses, chemical structure elucidation, and anticancer evaluation. There are two main parts to this section chemistry and biology.