الفهرس 
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Abstract
Cystic fibrosis is a chronic autosomal recessive hereditary potentially life-threatening disease caused by mutations of CFTR gene on chromosome 7.
The study aimed to assess the incidence of lower respiratory tract fungal infections among cystic fibrosis pediatric patients in Chest department at Ain Shams University Pediatric Hospital and to correlate fungal culture results with the patient clinical status.
The study was applied on 32 CF patients from whom lower respiratory samples were collected and sent to the Main Microbiology Laboratory, Clinical Pathology Department, Ain Shams University Hospitals for routine microbiological cultures.
As regard specific CF laboratory test, all the patients were positive for sweat chloride test (> 60 mmol/l). Among 19 cases (59.3%) tested for CF gene mutation, F508 del mutation was the most common CFTR mutation detected in nine cases (64.3 %).
Bacterial growth was detected in five samples (15.6%), where pseudomonas spp was the most frequent pathogen detected in four samples and one sample showed mixed growth of pseudomonas spp and MRSA. Fungal growth was detected in three samples (9.4%), where Candida spp was the fungal species detected in all; one sample (3.1%) showed growth of Candida albicans and two samples (6.3%) showed growth of Candida non albicans.