الفهرس 
Title : Evaluation Of The Prophylactic And Therapeutic Effects Of Selenium And Vitamin E On The Muscular Phase Of Experimental Trichinella Spiralis Infection In Mice
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Abstract
Trichinellosis is one of the most common foodborne parasitic infections that can lead to muscle damage and necrosis. The present study evaluated the prophylactic and therapeutic impact of the antioxidants selenium (Se) and vitamin E on experimental Trichinella spiralis (T. spiralis) infection in mice. A total of sixty male Swiss albino mice were divided into 3 main groups; the control, the prophylactic, and the therapeutic groups, with further subgroups division according to the received treatment. Parasitological, histopathological and biochemical assessments were performed to evaluate the influence of the used vitamin E and Se. For the parasitological assessment, all the treated groups showed statistically significant reduction in larvae count/gm muscle compared to the infected control group. In the prophylactic group, combined Se and vitamin E achieved the highest reduction, 58.4% and 51% in diaphragm and intercostals, respectively. Whereas in the therapeutic group combined ALB-Se-vitamin E showed the maximum reduction rates of 90.4% and 84.4% in diaphragm and intercostals, respectively. Histopathological assessment was in correlation with parasitological results as the groups receiving combined therapy showed marked improvement in degree of inflammation, number of nurse cells and larval degeneration. Biochemical assessment for oxidative stress markers (Malondialdehyde (MDA) and Superoxide dismutase (SOD)) levels in treated muscle tissues showed a marked decrease in both prophylactic and therapeutic groups. In conclusion, Se and vitamin E demonstrated an antiparasitic, anti-inflammatory & antioxidant effects on the muscular phase of trichinosis.