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العنوان
PNPLA3 and Neutrophil Lymphocyte Ratio as a Genetic and Inflammatory Predictors of Histopathological Severity by Liver Biopsy in Non-alcoholic Fatty Liver Disease/
المؤلف
Abu Bakr,Heba Mohamed Abu Bakr
هيئة الاعداد
باحث / هبه محمد ابوبكر
مشرف / إيناس محمود فوده
مشرف / شيرين أبوبكر صالح
مشرف / محب شرابى اسكندروس
مشرف / غاده عبد الرحمن
مشرف / نشوى ناجي الخزرجي
تاريخ النشر
2023
عدد الصفحات
134.p:
اللغة
الإنجليزية
الدرجة
الدكتوراه
التخصص
الطب الباطني
تاريخ الإجازة
1/1/2023
مكان الإجازة
جامعة عين شمس - كلية الطب - Internal Medicine
الفهرس
Only 14 pages are availabe for public view

from 135

from 135

Abstract

group, with most NAFLD patients having the homozygous GG variant. The study also found a significant difference between the PNPLA3 gene variant and steatosis percentage in NAFLD patients. However, there was no significant difference between the PNPLA3 gene variant and other clinical markers, including hepatic cell ballooning, fibrosis, glycemic status, liver enzymes, lipid profile, N/L ratio, or MPV.
Conclusion: NAFLD is more common in subjects with Homozygous GG variant of PNPLA3 gene. NAFLD patients with Homozygous GG variant of PNPLA3 gene are more prone to high grade of steatosis. Liver cell ballooning and liver fibrosis have no relation with different variants of PNPLA3 gene. Neutrophil to lymphocyte ratio (N/L ratio) and mean platlet volume (MPV) are good inflammatory markers to detect NAFLD.