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العنوان
Serum level of microrna-15a and interleukin 6 as biomarkers for sepsis in critically ill patients /
المؤلف
Doaa Nader Abdelhameed Elsaied,
هيئة الاعداد
باحث / Doaa Nader Abdelhameed Elsaied
مشرف / Mona Abdelwahab Abdelmaseeh
مشرف / Nermin Samir Rashwan
مشرف / Rania Elsharif Alhoseiny
الموضوع
Biomarker
تاريخ النشر
2022.
عدد الصفحات
109 p. :
اللغة
الإنجليزية
الدرجة
الدكتوراه
التخصص
علم المناعة والحساسية
تاريخ الإجازة
1/1/2022
مكان الإجازة
جامعة القاهرة - كلية الطب - Medical Microbiology and Immunology
الفهرس
Only 14 pages are availabe for public view

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Abstract

Sepsis is a complex disease with multiple severe consequences on the patient and on the medical health system. Numerous sepsis biomarkers are available for diagnosis and prognosis however, they have low to moderate sensitivity and specificity. In the present study, serum IL-6 concentration was measured using ELISA, while serum microRNA 15a was measured by qRT-PCR. Both serum IL-6 and miRNA 15a were found to be upregulated in sepsis patients compared to non-sepsis patients admitted to the medical ICU. Moreover, miRNA 15a showed high sensitivity and specificity as a diagnostic biomarker for sepsis