الفهرس 
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Abstract
Keloids are macroscopic cutaneous scarring resulted from disturbance of wound healing that occurs in predisposed individuals. Several treatment options were reported to induce clinical improvement but with variable results. Of these options intralesional BTX-A and cryotherapy were novel alternatives with promising results.
In the current study we compared the clinical efficacy and safety of intralesional BTX-A and cryotherapy in the treatment of keloids and to assess their effect histopathologically and immunohistochemically on fibronectin expression.
Ten patients complaining of keloids (at least 2 lesions) were enrolled. Keloids were treated by either cryotherapy or intralesional BTX-A. Clinical, histological and immunohistochemical response were recorded with both treatments.
Assessment of treatment response with either treatment revealed that there was statistically significant decrease in keloid pliability, height and total VSS score after treatment compared to before treatment. In addition, there was statistically significant decrease in epidermal thickness and fibronectin spot count after treatment compared to before treatment. Correlation of fibronectin spot count and duration of scar revealed statistically significant positive correlation of epidermal thickness and duration of scar before either therapy.
Side effects encountered were minimal and both treatments were well tolerated by studied patients.