الفهرس 
IntroductionOnly 14 pages are availabe for public view
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Abstract
Uteropelvic junction obstruction is one of the most common urological anomalies in the pediatric urology and the most common cause of hydronephrosis in pediatric age group, many studies sought explanation for its cause and yet its etiology is still controversial.
Comparing the quantitative changes in the interstitial cells of Cajal (ICC) between specimens with UPJO and specimens without hydronephrosis using light microscopy and correlating these changes to the etiology of the disease was done in our study.
In the period between February 2020 and February 2022 a cohort study at our center on 17 patients (13 males and 4 females) with UPJO that underwent Anderson Hynes pyeloplasty and 2 control patients without obstruction that underwent total nephrectomy and both groups were compared immunohistochemically with c-kit (CD117) to quantify the ICC which are located near the circular muscle layer and parallel to the muscle cells.
On light microscopic examination, it was determined that the density of interstitial cells of Cajal in the UPJO group was significantly low compared to the number of ICC in control group as seen in the summary table.