الفهرس 
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Abstract
S
UMMARY
n patients with diabetes mellitus (DM), compared with those without DM, coronary artery disease (CAD) tends to be more diffuse, complex, and associated with increased morbidity and mortality from cardiovascular disease.
The SYNTAX score (SS) uses coronary anatomy to objectively guide decisions regarding mode of revascularization. The SYNTAX score characterizes the extent of coronary disease in terms of the number of lesions, their functional importance, and their complexity.
The number of diseased coronary vessels is not the only marker for CAD severity. The location of the lesions and their impact on blood flow, the degree of vessel stenosis, lesion classifications, and the diameter and calcification of the vessel are also important factors that affect the technical feasibility of performing PCI, and the prognosis. Considering these factors, there are different degrees of multivessel disease and the preferred revascularisation strategy may be different for specific lesion complexities. To assess this hypothesis the angiographic SYNTAX score and GENSINI score were introduced.
The aim of this study was to assess the correlation between Fructosamine Level and the severity of coronary artery disease by calculating SYNTAX score and GENSINI score in
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diabetic patients presenting to Ain Shams University Hospital with symptomatic chronic coronary syndrome undergoing elective coronary angiography.
This study was conducted on 200 diabetic patients with chronic coronary syndrome undergoing elective coronary angiography, with mean age 54.36 ± 5.86 years ranging from 32 years to 65 years. The majority of them were males (64%).
As regards risk factor among this study population; 57% were smokers, with mean smoking index 1.87 ± 0.87 ranging from 0.5 to 4. The majority of the patients in this study were hypertensive (74.50%). Diabetes complications were found in 7% of the study population (PVD).
Regarding hyperlipidemia among the study population: the mean low density lipoprotein (LDL) was 149.14 ± 45.7 u/l. The mean HDL was 43.41 ± 10.56 u/l. The mean TAG was 216.24 ± 89.82. Cholesterol ranged from 95 to 396 with mean 225.88 ± 60.
CAD history among the study population was reported in 43% of patients. 5.50% of the patients had past history of ACS. 20%, 14.50% and 1.50% of patients underwent CA, PCI and CABG, respectively.
CVD history among the study population was detected in 8% of patients. 7% patients with PVD, 1% patients with
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STROKE, while no patients had hemorrhage. FAMILY HISTORY of CAD was found in 22.50% of the patients.
HbA1C in the study population ranged from 6.5 to 14.3 with mean 9.61 ± 2.01, while Fructosamine level in the study population ranged from 201 to 653 with mean 392.31 ± 123.28.
SYNTAX score in the study population ranged from 4 to 58 with mean 25.4 ± 11.09, while GENSINI score ranged from 4 to 160 with mean 58.86 ± 37.92.
There was a strong positive relationship between Fructosamine and HbA1C, with 0.855 correlation coefficients.
There was a strong positive relationship between Fructosamine and SYNTAX score, with 0.668 Correlation Coefficient. There is significant Correlation between Fructosamine and SYNTAX score third tertile (>32).
Pearson’s Correlation Coefficient between Fructosamine and GENSINI score was 0.734, which means that there was a strong positive relationship between Fructosamine and GENSINI score. There is significant Correlation between Fructosamine and GENSINI score third tertile (>38).
Pearson’s Correlation Coefficient between HbA1C and syntax score was 0.636, which means that there was a strong positive relationship between HbA1C and syntax score.
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Pearson’s Correlation Coefficient (r) between HbA1C and GENSINI score was 0.716, Which means that there was a strong positive relationship between HbA1C and GENSINI score.
In conclusion a significant correlation was detected between serum Fructosamine Level and severity of coronary artery disease assessed by the angiographically derived SYNTAX and GENSINI scores in diabetic patients with symptomatic chronic coronary syndrome.