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Abstract
Childhood obesity is one of the most serious public health problems facing the developed and increasingly, the developing world. In this study, we aimed to investigate the possible role of thyroid hormones and some adipocytokines in childhood obesity. A total of 80 children were enrolled; 50 obese children and 30 non-obese of matched age and sex. Clinical, demographic characteristics and lipid profile levels were monitored. Plasma levels of thyroid hormones (Thyroid stimulating hormone; TSH, thyroxine; T4 and triiodothyronine; T3), leptin, interleukin 1- alpha (IL1-Ü) and tumor necrosis factor- alpha (TNF-Ü), as well as urinary iodine were measured in these subjects. Dyslipidemia, in terms of increased total cholesterol (T.ch), low density lipoprotein- cholesterol (LDL-c) and triglycerides (TG) levels along with decreased high density lipoprotein- cholesterol (HDL-c) levels, was evident in obese children relative to normal ones. Obese children exhibited a significant reduction in TSH and free- T4 levels. Meanwhile, the levels of total- T3, free- T3 and urinary iodine output were insignificantly changed. There was an increment in both leptin and IL1-Ü levels of obese children, however, their TNF-Ü levels were significantly decreased. Alterations in thyroid hormones status, leptin, IL1-Ü and TNF-Ü might be implicated in the etiology of obesity associated with Egyptian children