الفهرس 
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Abstract
HCC is the sixth and fourth common cancer in worldwide and Egypt, respectively. Egypt ranks the third and 15th most populous country in Africa and worldwide, respectively. HCC occurs most often in people with chronic liver diseases, such as cirrhosis caused by hepatitis B or hepatitis C infection, the cell proliferation and the expression of the apoptosis-related gens (p53) have been suggested to be important factors in the genesis of HCC. Under a sustained environmental stress, reactive oxygen species (ROS) are produced over a long time, and thus significant damage may occur to cell structure and functions.
The present study investigates the possibility of using 8-OHdG as an oxidative stress marker to predict HCC development in chronic liver disease patients and to monitor the progression of HCC.
Chapter I, contains a review of literature survey includes pathogenicity of HCV-related liver diseases and their role in HCC development. Chapter II, involves materials and methods used to evaluate (8-OHdG), (TP53) and (AFP) levels in the sera of all participating groups. Chapter III and Chapter IV, include the results and discussion, respectively abstracted from this study.