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العنوان
Study on sources and effect of microbial contamination on stability of certain non-sterile preserved oral pharmaceutical products /
الناشر
Lobna Aref Abdelrazak Bahnsi Deif ,
المؤلف
Lobna Aref Abdelrazak Bahnsi Deif
تاريخ النشر
2017
عدد الصفحات
66 P. :
الفهرس
Only 14 pages are availabe for public view

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Abstract

In this study, two types of preserved syrup with different preservative were chosen to study types, sources of contaminants including environmental condition as air, raw materials and water. from 400 different samples of finished product, 3 bacterial and 39 fungal isolates had been isolated. However, the following microbes isolated: 64 fungal isolates in addition to 188 bacterial isolates were isolated from air samples.Only four bacterial isolates were isolated from sucrose. However, microbiological analysis of other raw material did not result in any bacterial or fungal isolates. Finally, only three bacterial isolates were isolated from water included in formulation of finished product. Aspergillusflavuswasthemostcommonfungusisolatedamong 31and25fungalisolates fromair andfinished syrupsamplesrespectively. The genetic relationship between numberof isolated Asp. flavus (20randomsamples) using RAPD PCR technique was studiedandillustratedin form of dendrogram. Obtaineddendrogramshowedthattherewasgeneticrelatednessbetweenfungiisolatedfromairandfungiisolatedfromfinishedproductwith72%to32%