الفهرس Only 14 pages are availabe for public view
 |  | from | 173 |  |  |
| | | from | 173 | | |
Abstract
This work deals with the synthesis of novel structures of: 1-[(2-hydroxyethyl)(aryl)amino]-N-substituted cycloalkanecarboxamides (IXa-l) and 2-[(1-substituted carbamoyl)cycloalkyl)(aryl)amino] ethyl acetates (Xa-l) derived from certain diazaspiroalkanediones. The newly synthesized compounds displayed an anticonvulsant activity using the subcutaneous pentylenetetrazole (scPTZ) and maximal electroshock seizure (MES) tests. The compounds were devoid of neurotoxicity in rotarod test. The most potent compounds in the scPTZ screen were Xh, Xd, Xf, IXj, Xl and Xi. Compound Xf was active as a new anticonvulsant agent in both scPTZ and MES screens. Also, a molecular modeling study was performed for the designed target compounds using Autodock 1.5.6