الفهرس 
Introduction and aim of the workOnly 14 pages are availabe for public view
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Abstract
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The present study was designed to evaluate the potential therapeutic effects of ottelione A (OTTE) against carbon tetrachloride(CCl4)-induced toxicity in mice. Adult male Swiss albino mice were divided into six groups: group I was used as a normal control received olive oil; group II received DMSO; group III received OTTE; group IV received CCl4 in olive oil, (injected i.p.) 3 times/week for 6 weeks; group V received the same CCl4 regimen as group IV followed by OTTE injected for 15 days, and group VI first received OTTE injected for 15 days followed by the same CCl4 regimen as group IV. Some biochemical, hematological, and histological parameters were investigated. Our results showed that the administration of CCl4 caused hepatotoxicity, as monitored by the significant increase in biochemical and hematological parameters concerning the olive oil group Treatment with OTTE appeared to be effective against hepatotoxic and liver changes induced by CCl4, as evidenced by the improvement of these same parameters. Generally, these results show that OTTE has good antioxidant and therapeutic properties.