الفهرس 
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Abstract
Introduction: Plasma levels of non-enzymatic antioxidants and antioxidant enzyme activity looked to be lower in patients with mild cognitive impairment (MCI), which increased the rate of neuronal damage and increased the likelihood that MCI would quickly advance to dementia.
Objective: To evaluate the correlation between oxidative stress and cognitive decline in elderly with mild cognitive impairment.
Methods: For this investigation, there were 40 senior patients with cognitive impairment who were 60 years or older, as well as 40 healthy controls who were the same age and sex. Serum malondialdehyde (MDA), antioxidant indicators, and assessments of cognitive function, depression, nutrition, functional ability, and fall risk were performed on all individuals (superoxide dismutase and catalase).
Results: Serum Malondialdehyde were higher in MCI group (p<0.001) while superoxide dismutase and catalase were significantly lower in MCI group (p<0.001). Catalase ≤100.0 U/mL had perfect diagnostic value for MCI with sensitivity and specificity of 100%, followed by MDA ≥75.0 U/mL with sensitivity and specificity of 100% and 97.5% and
SOD ≤61.0 U/mL with sensitivity and specificity of 100% and 75% (p <0.001).
Conclusion: Oxidative stress play a role in development of MCI with decrease level of antioxidant while increase level of oxidative damage products, comparing the efficacy of markers of oxidative damage as well as antioxidant in diagnosis of MCI and their cutoff point, the study concluded that Catalase (≤100.0 U/mL), followed by MDA (≥ 75u/ml) then SOD (≤ 61.0 u/ml)