الفهرس 
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Abstract
HCC is the most common type of primary liver cancer, which accounts for 80-90% of malignancies of liver cancer. The majority of HCC patients are detected when the disease has progressed to the point where surgery is no longer an option. Chemotherapy, which is the primary therapeutic option for advanced HCC patients benefits less than one-third of these patients. Drug resistance, unpleasant side effects, and high cost remain barriers to effective chemotherapy treatment, this spurred many researchers to find and create natural product-derived drugs for treating cancer with higher therapeutic efficacy, lower cost, and fewer side effects. IQ and SF are natural safe substances derived from different types of plants that exhibit efficient anticancer, antioxidant, and anti-inflammatory effects recognized as a promising chemo-preventive agent against many kinds of cancers including hepatic cancer.
Despite substantial published research on the health benefits of isoquercetin and sulforaphane, investigations on their effectiveness against HCC are uncommon. The majority of previous investigations on the anticarcinogenic action of these drugs in liver cells were conducted in vitro, on the other hand, those conducted in experimental animals looked at the preventive effects on early stages of HCC or the transplanted tumors in nude mice.
As a result, the goal of this study was to assess the effects of isoquercetin (10, 20 mg/kg bw) and sulforaphane (2mg/kg bw) against advanced stages of HCC in vivo, as well as to illustrate the mechanism of action of these substances as anticancer drugs by measuring some related markers such as tumor suppressor protein “P53”, angiogenesis marker “VEGF” and proliferating marker “PCNA”, in addition, we assess the endogenous antioxidant capacity of these natural drugs by measuring TAC and also measured lipid peroxidation through assessing MDA.
Our result demonstrated that IQ (especially 20 mg/kg bw) and SF ameliorate the structure and function of HCC animal’s liver, enhancing the survival rate, reducing AFP, ALT, AST, and the number of hepatic nodules, and downstaging HCC. On the other hand, these natural products increase TAC and p53, while MDA, PCNA, and VEGF levels were reduced.