الفهرس 
Effect of cyclin D1 on the prognosis of multiple myeloma in Egyptian patients
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Abstract
Background: Multiple myeloma is a disseminated malignancy of monoclonal plasma cells, diagnosed by {u2265}10% clonal bone marrow plasma cells or a biopsy infiltrated by plasma cells along with one or more of the multiple myeloma defining events (MDE): CRAB (hypercalcemia, renal failure, anemia, or lytic bone lesions). Aim of work: Correlating Cyclin D1 with the prognosis of the patients. Subjects, materials and methods: Bone marrow biopsy of 50 patients newly diagnosed as Multiple myeloma were examined by immunohistochemistry for Cyclin D1, then these patients were followed up for a year. Results: There was significant correlation between Cyclin D1 and response of the patients. Conclusion: Cyclin D1 positive patients were found more likely to have worse prognosis than the negative ones