الفهرس 
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Abstract
Introduction: Vitiligo is a multifactorial disease characterized by a deficiency or absence of skin pigmentation due to the loss or inactivity of melanocytes in the basal layer of the epidermis or mucosa (Said-Fernandez et al., 2021). Over the past years, numerous studies reported that the complex interaction among genetic, environmental, biochemical, and immunologic factors produces a micro-environment that favours loss of melanocytes in vitiligo (Kundu et al., 2019; Jadeja et al., 2021). Autoimmunity is the most widely accepted hypothesis to explain the pathogenesis of non-segmental vitiligo (Furue and Kadono, 2016). The Aim of this study: This work was made in an attempt to assess possible relation between IL-27 and IL-37 in pathogenesis of non-segmental vitiligo. Subjects and methods: A case-control study enrolled 40 patients with non-segmental vitiligo and 40 healthy age- and sex-matched controls. IL-27 and IL-37 levels were measured in venous blood samples using ELISA. Results: Lower IL-27 level was detected among patients versus controls, however, higher IL-37 level was detected among patients versus controls. A statistically significant difference was found between patients and controls as regard IL-27 &IL-37 (P<0.001). These findings might indicate possible relation between both IL-27 & IL-37 and pathogenesis of non-segmental vitiligo. Conclusion: • There are possible roles of both IL-27 and IL-37 in the etiopathogenesis of vitiligo. • IL-37 might have a great validity to be utilized as a biomarker for assessing both activity and severity of vitiligo. • IL-27 has an immunomodulatory role in vitiligo. Keywords: Interleukin-27, Interleukin-37, Non-Segmental Vitiligo