الفهرس 
OBESITY AND CO-MORBIDITIESOnly 14 pages are availabe for public view
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Abstract
Obesity is one of the major health problems affecting population health and life all over the world. It is associated with serious co-morbidities including coronary heart diseases, diabetes, hypertension and respiratory diseases. The frequency of laparoscopic bariatric surgery has been increasing worldwide for patients with medically complicated obesity especially who have difficulty in losing weight by conservative methods.
However, the pneumoperitoneum created during laparoscopy can produce stress cardiovascular response with hemodynamic alterations leading to abrupt elevation of mean arterial pressure (MAP), mean pulmonary artery pressure, heart rate (HR), and systemic vascular resistance.
Magnesium plays a critical role in a variety of physiologic processes. Although magnesium is not a primary analgesic in itself, it enhances the analgesic actions of more established analgesics as an adjuvant agent. Studies demonstrated that magnesium is an antagonist of N-methyl-d-aspartate glutamate (NMDA) receptors, which can affect pain perception and duration.
In this study, MgSO4 administration via intraperitoneal route was found to have a significant effect on pain management, hemodynamic response, PONV and sedation in comparison to IV route.
Intraperitoneal magnesium sulphate instillation is a safe technique that has better results than intravenous infusion in attenuation of hemodynamic response with pneumoperitoneum, pain management and PONV with laparoscopic mini gastric bypass patients.