الفهرس 
AUTISM SPECTRUM DISORDERS: AN OVERVIEW ON DIAGNOSIS AND TREATMENTOnly 14 pages are availabe for public view
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Abstract
Background: Objectives: Autism spectrum disorder (ASD) is a developmental disorder characterized by deficits in social interaction, restricted interest and repetitive behavior. Oxidative stress in response to environmental exposure plays a role in virtually every human disease and represents a significant avenue of research into the etiology of ASD. The aim of this study is to asses 8-hydroxy-2’-deoxyguanosine (8-OH-dG) level in urine as a urinary marker of oxidative stress in children with autism spectrum disorder in comparison to sex and age matched healthy control group Patients and methods: : We included 51 children with autism (43 males and 8 females, age range from 2 to 16 years). 51 children of the same age were selected as a control group. The diagnosis of autism was made based on the criteria of autistic disorders as defined in the Diagnostic and Statistical Manual of Mental Disorders, Fifth Edition (DSMV)
Detailed medical history included sociodemographic form and family history is taken for autistic group also IQ test and CARS used to measure the severity of autism. In the study, 8-OHdG values in urine were investigated using the ELISA method and Urinary creatinine was determined with the Beckham Coulter analyzer and was used to normalize all biochemical measurements then the urinary 8-OHdG/creatinine levels were corrected to the urinary concentration of creatinine. Results: Fifty-one cases with autism (88.2% males) and fifty-one healthy controls (84.3%males) were included in the present study (P =0.565). The median age was 9.9 in the ASD group and 9.1 in the control group (P = 0.256). In the ASD group, (8-OH-dG)/creatinine ratio values were found to be significantly higher than those of the controls (P < 0.001). Conclusion: The data from this study support the hypothesis of the oxidant/antioxidant balance as a key piece that may contribute to autistic pathology, however, explanation of the underlying molecular mechanism is currently underway. The growing recognition that oxidative stress is involved in the pathogenesis of autism has generated considerable interest to identify early biological markers that may help develop earlier clinical, therapeutic or preventive strategies.