الفهرس 
Title : Screening for Cytomegalovirus in pregnant women with or without liver diseases
AbstractOnly 14 pages are availabe for public view
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Abstract
Introduction: CMV infection is present worldwide and can be presented from a mild clinical picture, similar to cold, to an extremely severe form of illness in immunocompromised individuals. CMV transmission occurs from person to person via body fluids, and requires close contact with contaminated secretions .The transmission mode is vertical and horizontal. In developing countries, most infections occur during childhood. Aim of work: Detect the prevalence of CMV infection among the pregnant women, Also to detect the changes of liver stiffness in relation to pregnancy in patients who were infected or not with CMV and to compare the obstetric outcome for pregnant women with and without CMV infection. Patients and method: This study included 201 pregnant ladies presented to the liver disease with pregnancy clinic, Endemic medicine department and obstetric outpatients clinic, Faculty of medicine, Cairo University. Patients who were included in this study underwent CMV testing, which includes CMV IgG, CMV IgM and CMV DNA by PCR for CMV serology positive only. ARFI was done for 130 pregnant women, Follow up by ARFI was done for 114 women after puerperium.Result: CMV prevalence IgG +ve 52.7% , IgM +ve 11.9%, PCR+ve11.9%. Pregnancy outcome significantly different between pregnant with no CMV infection and those with CMV infection, even she had (previous, chronic, recent or current CMV infection) regarding abnormal outcome of pregnancy in pregnant with no CMV infection and those with CMV infection 9.47% and 18.87% respectively. Baseline ARFI and post partum ARFI were significant, post partum ARFI decreased in normal group and group with pregnancy associated liver disease but not decreased in pregnant with liver disease not related to pregnancy