الفهرس 
Title : Improvement of the physicochemical properties and bioavailability of a certain antipsychotic drug
ContentsOnly 14 pages are availabe for public view
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Abstract
Schizophrenia, a devastating and chronic psychotic disease, is a heterogeneous syndrome characterized by perturbation of language, perception, social activity, affection and volition. Schizophrenia is an illness characterized by a group of so-called 2positive3 symptoms that may include hallucinations (hearing voices, seeing visions), delusions (fixed false beliefs), and/or a thought disorder (speech that makes little sense).Olanzapine is a practically insoluble antipsychotic drug which is subjected to excessive first pass effect and shows inadequate oral bioavailability.Nanostructured lipid carrier (NLC) is the second-generation lipid nano carriers composed of solid lipid matrix that are incorporated with liquid lipids. This carrier system is made up of physiological, biodegradable and biocompatible lipid materials and surfactants and is accepted by regulatory authorities for application in different drug delivery systems. The availability of many products in the market in short span of time reveals the success story of this delivery system. Therefore, mesoporous silica was used to improve physicochemical properties and bioavailability of olanzapine incorporated in nano-structured lipid carriers (NLCs). Freeze-drying is a widely used process for drying and improving the stability of various pharmaceutical products including viruses, vaccines, proteins, peptides or colloidal carriers: liposomes, nanoparticles, nano emulsions