الفهرس 
Expression of some microRNAs in exosomes of peripheral blood and placental-derived mesenchymal stem cells from Egyptian patients with pre-eclampsia
AbstractOnly 14 pages are availabe for public view
 |  | from | 101 |  |  |
| | | from | 101 | | |
Abstract
Pre-eclampsia (PE) is one of the most threatening pregnancy complications. So far neither a secure, competent therapy for PE nor effective biomarkers for a premature discovery has been achieved. However, the use of released microRNAs (miRNAs) as potential biomarkers and therapeutic targets for various diseases is currently the dominating area of research. The aim of the present study was to identify miRNAs 136, 494, and 495 genes expression in exosomes of peripheral blood compared to umbilical cord mesenchymal stem cells (UCMSCs) conditioned media released exosomes in patients with PE, as valuable markers for PE early prediction. This study further aimed at implementing the role of these miRNAs in the poor angiogenesis process during PE, by assessing the quantitative expression of vascular endothelial growth factor (VEGF) in exosomes of peripheral blood and UCMSCs from both PE and normal pregnancies. Blood samples were collected from 100 patients with PE and 100 control with normal pregnancies. Thirty fresh umbilical cord samples of women with healthy pregnancies (n=15) and PE patients (n=15) were retrieved during cesarean deliveries and UCMSCs were isolated from Wharton jelly