الفهرس 
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Abstract
This thesis aimed to develop and evaluate self-emulsifying drug delivery systems (SEDDS) containing simvastatin to increase its oral bioavailability. Thirty formulations were evaluated for stability, robustness to dilution and self-emulsification time. Nine formulations were assessed for cloud point, mean droplet size, polydispersity index (PDI), zeta potential and in-vitro drug release. After oral administration of a single dose of simvastatin loaded SNEDDS (CL14 and EO 5), 1.5-fold and 1.95-fold increase in bioavailability were observed, respectively, as compared to simvastatin suspension. selected formulations demonstrated a superior anti-hyperlipidemic activity in comparison to pure simvastatin suspension.