الفهرس 
REVIEW OF LITERATURE EMERGENCE AGITATIONOnly 14 pages are availabe for public view
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Abstract
SUMMARY
This recent clinical trial was to compare the effectiveness of reduction of occurrence of the emergence agitation after nasal surgery in adults by administration of melatonin versus mirtazapine.
After approval of the anesthesiology department and scientific and ethical committe, this prospective randomized clinical trial study was conducted at Ain Shams University Hospitals,Cairo, Egypt.
One hundred and sixty five (165) consecutive patients scheduled for elective nasal surgery under general anesthesia where nasal packing was packed in both sides. The patients’ age was above 21 years old from both genders and with the American Society of Anesthesiologists physical status classification (ASA) I or II.
The study aim, drug probabilities were given to the patient and their mode of action and side effects were explained to the patient who freely accepted the study and a written consent was obtained from each patient. The patients included in the study were chosen with body mass index (BMI) <30.
Patients were randomly assigned into one of the following 3 groups using computer generated codes hidden in sealed opaque envelopes; Mirtazapine group (group I) (n=55); each patient received mirtazapine 30 mg tablet and a placebo capsule (matching melatonin) with sips of water, Melatonin group (group II) (n=55); each patient received melatonin 5 mg Capsule and a placebo tablet (matching mirtazapine) with sips of water and a Control group (group III) (n=55); each patient received a placebo capsule and a placebo tablet (matching melatonin and mirtazapine) with sips of water.
The attending anesthetist, surgeons, recovery nurses and patients were blinded to the group assignment. All medications given to every group patients including the matching placebo tablets were identical and were prepared by the local pharmacy in the hospital and were handled to the ward nurses; Ward nurses and anesthesiologist in charge were blinded to the nature of the study medication and groups assignment.
This study is a trial phase 4 study. This study was conducted by competent investigators blinded to drug intervention and group assignments of patients.
This clinical trial indicated that mirtazapine could be an option for prevention of agitation in patients with nasal surgery. To our knowledge this is first study in the literature to research the efficacy of mirtazapine in prevention of agitation in patients having nasal surgeries.