الفهرس 
INTRODUCTIONOnly 14 pages are availabe for public view
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Abstract
More than 50% of the human populations have long-term H. pylori infection, causing, in some cases, severe diseases such as peptic ulcers and stomach cancer. In the last few years, several extra-gastrointestinal disorders have been associated with H. pylori infection. These were been caused by induction of a strong inflammatory response with the release of various bacterial and host-dependent cytotoxic substances.
Recent evidence suggests that H. pylori infections play a role in the patho- genesis of a variety of skin diseases such as chronic urticaria, rosacea, alopecia areata, atopic dermatitis, generalized pruritis, lichen planus and recurrent aphthus stomatitis, Behçet’s disease, nodular prurigo, idiopathic thrombocytopenic purpura, Schoenlein-Henoch purpura, Sjögren syndrome and Sweet syndrome.
Depending on all these facts regarding the relation between H. pylori and skin diseases, this study was designed aiming at detecting that relation.
group (1) of this study was conducted on 202 patients categorized into study sub-group of 101 patients, complained of one of the following skin diseases, acne rosacea, chronic urticaria, atopic dermatitis, generalized pruritis, recurrent aphthus stomatitis or lichen planus. Also, control sub-group of 101 healthy individuals and matched with patients for age and sex. Both sub-groups were attending dermatology clinic in Suez Canal university hospital.
group (2) of this study was conducted on 64 patients with dyspeptic symptoms categorized into study sub-group of 32 patients with positive H. pylori (by histopathological diagnosis) and control sub-group of 32 individuals with negative H. pylori (by histopathological diagnosis) and matched with patients for age and sex. Interview data were obtained from both sub-groups through fulfilling the questionnaire from each patient individually. Both sub-groups were attending endoscopy unit in Suez Canal university hospital.
History was been taken thoroughly from all participants and physical examination was done. Stool antigens test was screened for each patient in-group (1) for detection of H. pylori infection with estimation of its quantity. Each patient of group (2), evaluated for the presence of any skin manifestations.
The results of group (1) revealed that some of non-infectious skin diseases such as - acne rosacea, chronic urticaria, atopic dermatitis, generalized pruritis, recurrent aphthus stomatitis or lichen planus - were been related to H. pylori infection gave P-value < 0.05 that was highly statistically significant. With a significant correlation between the severity of each skin diseases and H. pylori infection.
However, the results of group (2) did not confirm the relationship between H. pylori and non-infectious skin diseases gave p-value > 0.05 that was highly statistically insignificant.
Totally, we found a significant similarity of skin diseases between patients with positive H. pylori of both groups (group 1 & 2).
We concluded that in light of data, Helicobacter pylori play a role in causing of some of non-infectious skin diseases