الفهرس 
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Abstract
Immunity system responsible for protect healthy tissue from disease promoting factors. Nutrient availability has the potential to affect all aspects of the immune system. In general, deficiency of several nutrients will lead to impaired immune responses, and replenishment of those specific components will typically restore the affected responses. In human beings, nutrient deficiencies impaired the immune response. Besides, conditions associated with over nutrition such as cardiovascular disease.
The present work carried out to study the therapeutic and protective effect of feeding Myrrh against immunity inhibition causative to male rats for 4 weeks. Immunity inhibition of rats was done by treatment for individual each mouse, by placing them in a glass tube of the same size. The mouse is not able to move and close the two sides with making breathing holes and swings on the back in a dark place at a temperature of 4-5 °C for 3-4 hours.
The effect of feeding Myrrh was studied on feed-intake, body weight gains and feed efficiency ratio. Immunity function was tested by level of total lymphocytes count and analyzed immunity protein (IgG). GOT, GPT, Creatinine, Bilirubin, total protein, total Albumin, serum globulin and hemoglobin also measured. Histopathological examination for Thymus and spleen was also carried out.
A total of forty-eight adult Sprague Dawley male rates weighting (150-200) gm. were allocated 8 groups. First group was the (-ve) control, the second group was left as a (+ve) control group, groups (3, 4 & 5) were induced immunity Inhibition for them at the end of experiment and received Myrrh with (50, 100 & 150) gm/kg respectively. group (6, 7 & 8) were induced immunity Inhibition for them at the end of experiment and received Myrrh with (50, 100 & 150) gm/kg respectively.
At the end of experiment period, all rats were scarified, Thymus and Spleen were removed and weighted. And blood samples were collected for separation the serum for biochemical analysis. Thymus and Spleen was examined histopathological.
Results of this study revealed that, rats in group (+ve control), were induced immunity Inhibition for them at the start of experiment, shows a significant decreased values in levels of significant decrease in Total protein were 4.58±0.32 g/dl, globulin 14.62±0.18 mmol/l, albumin 3.68±0.13 g/dl, Hemoglobin 11.61±0.23 g/dl, Hematocrit 34.83±0.69 %, Lymphocytes 11.83±1.46 % and IgG 1201.67±29.30 mg/dl, while significant increasing in serum creatinine 2.48±0.24 Umol/l, total bilirubin 6.83±0.46 mmol/l, GPT 85.00±2.77 u/l and GOT 50.00±1.41 u/l. As well as lymphocytic necrosis with appearance of tangible body macrophages and congestion of blood vessel were detected in histopathological examinations of Thymus, lymphocytic necrosis and depletion with appearance of tangible body macrophages were detected in histopathological examinations of Spleen.
While rats in protective groups with Myrrh 50, 100 & 150 mg/kg in groups 3, 4 and 5 respectively, or therapeutic groups with Myrrh 50, 100 & 150 mg/kg groups 6, 7 and 8 respectively, shows unsignificant increased values in body weight gain and feed efficiency ratio compared to rats in group +ve control. Significant increased values recorded in Thymus relative weight of protective and therapeutic groups 3, 4, 5, 6, 7 and 8 were 0.75±0.09, 0.85±0.16, 0.83±0.20, 0.87±0.17, 0.81±0.18 and 0.79±0.18 (%) respectively compared to group 2 was 0.71±0.15 %. Biochemical analysis shows significant increased values in levels of immunity protein (IgG) were (1312.38±46.68, 1571.10±41.86, 1768.25±45.17, 1420.76±23.12, 1377.74±36.71 and 1662.38±47.98 mg/dl) when compared with untreated rats (+ve group 2) were 1201.67±29.30 mg/dl. Lymphocytes, total protein, albumin, globulin and hemoglobin also increased significantly compared to untreated rats, while significantly decreasing in serum creatinine, total bilirubin, GPT and GOT.
Histopathological examinations of Thymus of rats protected and treated with Myrrh, shows significant decreasing in lymphocytic necrosis with appearance of tangible body macrophages and congestion of blood vessel compared to (+ve control) rats. Also Histopathological examinations of Spleen shows significant decreasing in lymphocytic necrosis and depletion with appearance of tangible body macrophages compared to (+ve control) rats
Conclusion:
Consumption of Myrrh is very useful as its protective and has a therapeutic effect for immunity disorders where it increases the values of immunoglobulin (IgG), Lymphocytes, total protein, albumin, globulin and hemoglobin. Also, its protection against immunity disorders was important before its occurrence and helping to protect the body and raise its immune efficiency