الفهرس 
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Abstract
T
he use of sedatives is an essential cornerstone in the daily practice of intensive care. Many studies, proposed beneficial effects of dexmedetomidine on the microcirculation of patients in sepsis.
The study aimed primarily to elucidate possible positive effects of dexmedetomidine; a commonly used sedation modality on the microcirculation of septic patients who are mechanically ventilated, by observing its effect vs midazolam on PPI,Co2 Gap and ScvO2, and secondarily to; compare 28-day mortality rate, the length of ICU stay in both groups, as well as the efficacy of PPI measurement in comparison with global markers of perfusion (ScvO2, P(v-a)Co2) in assessment of the microcirculation.
The study was conducted on 128 randomly chosen patients in surgical ICU in Ain Shams University hospitals after approval of the medical ethical committee.
The results of the study revealed that there were no significant difference between the two groups regarding demographic data, or in SOFA score. The study revealed that using dexmedetomidine as a sedation option didn’t provide better peripheral perfusion in patients with sepsis Dexmedetomidine group showed statistically significant better 28 day. survival, but. without difference in ICU stay. Additionally, Peripheral Perfusion index efficiently correlated with the global markers of microcirculatory assessment(Scvo2, and P(v-a) CO2).