الفهرس 
Cystic Fibrosis (CF)Only 14 pages are availabe for public view
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Abstract
ABSTRACT
Background: Cystic fibrosis (CF) is a severe, autosomal recessive disease of high prevalence caused by mutations of the cystic fibrosis transmembrane conductance regulator (CFTR) gene which is located on the long arm of chromosome 7.
Objective:
Patients and Methods: This was a cross-sectional study conducted on 25 cystic fibrosis patients in the age group from 1 – 17 years in the Pediatric pulmonology clinic, Ain Shams University Children’s Hospital from the first of July 2020 to the end of January 2022. The patients were classified according to their oral glucose tolerance test results into CF patients with normal glucose tolerance (n=18) and CF patients with abnormal glucose tolerance (n=7).
Results: Our analysis also showed that the most important factor associated with abnormal glucose tolerance test was found to be multidrug resistant pseudomonas colonization. The previous findings highlight the need for routine screening of CF patients with Pseudomonas with OGTT to exclude CFRD or any abnormality in glucose tolerance in these patients for earlier management, decreasing the risk of complications and reducing the disease severity.
Conclusion: The current study demonstrated that abnormal glucose tolerance is not uncommon among the studied CF patients. Our results concluded that abnormal glucose tolerance was significantly associated with higher rates of multi-drug resistant pseudomonas colonization, frequent pulmonary exacerbations, increased disease severity and the risk of complications