الفهرس 
Corona VirusOnly 14 pages are availabe for public view
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Abstract
COVID-19 pandemic has brought new health threats and challenges to the world. However, the scientific progress over the last months has shed more light on several key questions concerning COVID-19-associated complications.
Acute respiratory distress syndrome (ARDS) is the main cause of mortality in COVID-19, however hepatic involvement in COVID-19 may correlate with overall disease severity and serve as a prognostic factor for the development of ARDS.
The aim if this study was to correlate acute liver injury in Covid-19 hospitalized patients with the severity of the disease. This retrospective study was conducted on 110 Egyptian patients who were admitted with Covid-19 infection & elevated liver enzymes.
Statistical analysis revealed the following:
- In total, 110 patients with positive SARS-CoV-2 PCR test were included in this study. The study population was mostly males with 58.2% and median age of the population was 65 years old.
- As regards to the morbidity status of the study population, 67.3% of the patient died due to disease severity, while 32.7% showed recovery.
- There was statistical significant relation between liver injury in terms of elevation of (AST-ALP-GGT-Bilirubin) and the increase in oxygen demand.
- As regards to the inflammatory markers, they significantly correlated with liver injury.
- On univariate analysis of mortality risks, Age as well as elevated levels of BUN/AST/ALP/GGT and ypoalbuminemia were found to be associated risk factors. Whereas on multivariate analysis, only GGT was found to be an independent risk factor of mortality.
- To conclude, acute liver injury is a significant cause of morbidity & mortality in hospitalized patients with Covid-19 and positively correlates with the severity of inflammation.