الفهرس 
REVIEW OF LITERATUREOnly 14 pages are availabe for public view
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Abstract
Beta-thalassemia is a chronic hemolytic anemia that is
inherited in an autosomal recessive manner. It is
characterized by reduced hemoglobin levels and red blood cell
production.
Assessment of serum autophagy related protein beclin1
in Egyptian adult beta thalathemic patients and Its relation to
ineffective erythropoiesis, transfusion requirements, iron
overload.
This is a case control study which was carried out at Ain
Shams university hospitals. Internal medicine department,
Clinical hematology and stem cell transplantation unit,
outpatient clinic and inpatient department, during the period
between January 2022 and August 2022.
Our study revealed significant decreased fertility
between patients group and control group (P= 0.011).
Transfusion-dependent beta-thalassemia males have a high
proportion of fertility impairment and iron overload might
contribute to disturbed sperm quality and testicular tissue
injury. Such findings might explain the high prevalence of
impaired fertility in transfusion-dependent beta-thalassemia
patients which agrees with our results.
Also our study revealed significant differences between
non-transfusion dependent group and transfusion-dependent
B
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group regarding spleen size (cm) below costal margin which
was increased in (TD group), transfusion per year
(ml/yr)(which was increased in (TD group), virology (HIV,
HCV,HBV) revealed that percentage of HCV+ve higher in (TD
group) with (P<0.001): Our study revealed significant
difference between non-transfusion-dependent group and
Transfusion-dependent group regarding percentage of patients
of with positive HCV which was increased in Transfusiondependent group (P=0.021): In our study Iron chelation therapy
was found to be given in a higher percentage of TD patients
compared to non TD patients (P<0.001).
Also our study revealed significant difference regarding
cardic function (EF%) between patients group and control
group (EF found to be lower in patients group than controls)
(P<0.001): Also our study showed that Beclin-1 level is
significantly higher in patients group compared to control
group (P<0.001). We couldn‘t find previous studies of Beclin-1
level in thalassemia patients. We postulate that Beclin 1 could
be used as a marker of worsening cardiac functions in
thalassemia patients, but further studies should measure serial
levels of Beclin 1 and correlate it with cardiac parameters over
longer periods of follow up.
Beclin 1 level increased in Adult Beta Thalasemia
patients and it can be used as a prognostic marker for Adult
Beta Thalasemia patients.