الفهرس 
IntroductionOnly 14 pages are availabe for public view
 |  | from | 88 |  |  |
| | | from | 88 | | |
Abstract
Pulmonary hypertension is a multifactorial disease with a high morbidity and mortality, right ventricular function is the most important predictor of morbidity and mortality in patients suffering from pulmonary hypertension.
Milrinone, a phosphodiesterase III inhibitor is commonly used during post cardiopulmonary bypass (CPB) period in combination with adrenaline or noradrenaline to decrease pulmonary artery pressure and to provide synergistic positive inotropic effect (Oztekin et al., 2007).
Levosimendan is a calcium sensitizing agent with inotropic, pulmonary vasodilatory, and cardioprotective properties (Hansen et al., 2018).
This study compared levosimendan with milrinone in improving pulmonary hypertension after cardiac surgeries.
In this study 40 Patients were assigned randomly by using a computer –generated table of random numbers, placing them in sealed envelopes, into two groups:
o group M: 20 Patients received milrinone
o group L:20 Patients received levosimandan
o In this study groups were compared in demographic data (in terms of age, sex, weight and height) and there was no statistically significant difference between groups (p-value > 0.05).
o Groups were compared as regard CPB and type of surgery and there was no statistically significant difference between groups (P-value >0.05)
o In this study Groups were compared in post operative data (in terms of systolic, diastolic blood pressure, heart rate, SPO2, CVP, UOP and extubation time) and there was no statistically significant difference between groups (p-value > 0.05).
o In this study Groups were compared in echo data (in terms of preoperative and postoperative TAPSE,RVSP and PAP).
o In levosimendan group there was statistically significant difference in pre and post operative TAPSE,PAP,RVSP (p value<0.001) there was significant decrease in RVSP and PAP, and significant increase in TAPSE
o In milrinone group there was statistically significant difference in pre, post operative TAPSE(p value>0.003) PAP, RVSP (P value <0.001)
o In this study we compared levosimendan vs milrinone in levosimendan group there was more significant increase of post operative TAPSE and in milrnone group there was more significant decrease of PAP and RVSP.
o In this study Groups were compared in Liver enzymes data (in terms of preoperative and postoperative AST and ALT).
o There was statistically significant difference groups received milrinone in pre,post operative AST, ALT(p value>0.001).there was increase in post operative AST and ALT
o And there was statistically insignificant difference groups received levosmendan in pre,post operative AST, ALT(P value<0.05)
o In this study Groups were compared in kidney function (in term of pre and post operative serum creatinine) There was no statistically significant difference between groups (p-value > 0.05)
o In this study Groups were compared in acid base data (in term of post operative PH) There was no statistically significant difference between groups (p-value > 0.05)
o In this study groups were compared in weaning from ventilators (within 24 hours post operative)
o There was no statistically significant difference between groups (p-value > 0.05)