الفهرس 
IntroductionOnly 14 pages are availabe for public view
 |  | from | 111 |  |  |
| | | from | 111 | | |
Abstract
Inflammatory bowel disease (IBD) is an idiopathic disease caused by a dysregulated immune response to host intestinal microflora. Although the etiology of IBD remains largely unknown, it involves a complex interaction between the genetic, environmental, or microbial factors and the immune responses.
The two major types of inflammatory bowel disease are ulcerative colitis (UC), which is limited to the colonic mucosa, and Crohn’s disease (CD), which can affect any segment of the gastrointestinal tract from the mouth to the anus.
The diagnosis of IBD is based on a combination of clinical presentation and endoscopic, radiologic, histologic, and pathologic findings. Laboratory testing is complementary in assessing disease severity and complications of disease. There is no single laboratory test that can make an unequivocal diagnosis of IBD. The sequence of testing is dependent on presenting clinical features.
The most utilized biomarker for ulcerative colitis and Crohn’s disease is faecal calprotectin, which is useful particularly for diagnosis and follow UP.
Resistin is an adipokine expressed and produced in adipocytes and immune cells, mainly peripheral blood mononuclear cells and macrophages. It circulates in humans in a concentration between 7 and 22 ng/ml. The mature protein has a tendency to form oligomers, thus circulating in human serum in several different lower molecular weight and higher molecular weight isoforms.
It acts in a pro-inflammatory manner through activation of nuclear factor-kappa B inflammatory pathways. Resistin has been associated with inflammatory processes because its expression in adipose tissue is induced by pro-inflammatory cytokines (IL-1β, IL-6, and TNF-α) via the NF-κB signaling pathway.
Resistin is increased in serum during active IBD and decreased in remission. several studies have explored its role as a disease biomarker.
In the current study , the group of ulcerative colitis patients are studied to investigate serum levels of Resistin to detect its relation with the activity of the disease.
The present study revealed a highly significant elevation of serum Resistin in active ulcerative colitis patients with p-value <0.001 which shows direct relationship between the activity of ulcerative colitis and serum Resistin.Resistin was positively correlated with inflammatory markers (CRP and ESR) in UC patients. And there is negative relation between resistin and Hb, fecal calprotectin.