الفهرس 
Title : Toxicological assessment of aluminum and ferric oxides nanoparticles on Nile tilapia; Oreochromis niloticus after rice husk treatment
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Abstract
The present study was designed to investigate the toxic effects of Fe₂O₃ & Al₂O₃ NPs in single and combined doses on O. niloticus using different biomarkers and to evaluate the adsorptive capacity of RH toward those NPs. The average hydrodynamic diameter and the measured zeta potential of Fe₂O₃ and Al₂O₃ NPs in water showed the high ability of Fe₂O₃ NPs to aggregate in water than Al₂O₃ NPs. Both studied NPs caused a decrease in RBCs, Hb, Hct and MHCH, with an obvious increase in MCV and MHC. Compared with control groups, our results showed a significant increase in plasma proteins, globulin, glucose, liver enzymes and kidney function biomarkers. While the recorded albumin and total lipids were significantly decreased. The oxidative biomarkers in liver and gills tissues of NPs exposed fish showed a significant reduction in GSH content and elevation in TBARS, GPx, CAT and SOD activities. The bioaccumulation of Fe and Al metals showed a significant increase compared with the control groups. The results revealed a tissue-specific distribution pattern as following: liver > kidney > gills > skin > muscles for Fe and liver > gills > kidney > skin > muscles for Al. Moreover, the bioaccumulation potency of iron was greater than that of aluminum in all studied tissues. The histological studies of liver, kidney and gills showed different histopathological alterations ranging from compensatory histological changes in the RH treated groups to severe histopathological damage in the untreated groups. Based on our results, Fe₂O₃ NPs were more toxic than Al₂O₃ NPs. The combined doses of both NPs showed more or less toxicity compared to single doses. Therefore, this point needs more studies to show the mode of interaction. Based on the all studied biomarkers, the rice husk is a good absorbent for both studied nanoparticles individually or combined