الفهرس 
Title : Preparation, characterization and biological activity of some transition metal ions complexes with coumarin derived Schiff bases
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Abstract
It is known that coumarin and triazole derivatives possess antimicrobial and anticancer activities. In the present study, new Schiff bases (Sbsc and Sbat) were prepared by the reaction of 8- acetyl-7-hydroxy-4-methylcoumarin with sulfaclozine (Sbsc) and 3- amion-1, 2, 4-triazole (Sbat). The solid metal complexes were created by the reaction of (Ag (I), Pd (II), Cu (II)) salts with Sbsc Schiff base. The mixed ligand complex was prepared by the reaction of Sbsc and ciprofloxacin with Zn (II) salt. Two new metal complexes of Sbat Schiff base were separated by the reaction of Sbat Schiff base with Ag (I) and Cu (II) salts. These Schiff bases were subjected to elemental and spectral analyses (mass, IR, NMR, and UV-Vis spectroscopy). Beside these analyses, the studied complexes were also subjected to TG analysis, molar conductance measurements, magnetic moment, SEM, EDX analysis, ESR and XRD measurements. The electronic structure, global properties and nonlinear optical parameters of Sbsc, Sbat were calculated at B3LYP/6- 31++(d,p) level of theory and their complexes were at the B3LYP/GENECP level. The compounds were estimated for their antimicrobial effect against some gram positive and gram negative bacteria. The antifungal assay was executed against some fungal species. Their anticancer activities were performed in vitro against MCF-7 (breast cancer) and HCT-116 (colon cancer) cell lines