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العنوان
Fetal fibronectin; a new tool for the prediction of successful induction of labor /
المؤلف
ALafifY, Manal Mohammed Ibrahim Hassan.
هيئة الاعداد
باحث / منال محمد ابراهيم حسن العفيفي
مشرف / حازم إسماعيل محمد
مشرف / محمد عبد الهادي محمد
مشرف / / ابراهيم إبراهيم سويدان
الموضوع
Labor (Obstetrics). Labor, Induced (Obstetrics).
تاريخ النشر
2021.
عدد الصفحات
86 p. ;
اللغة
الإنجليزية
الدرجة
ماجستير
التخصص
أمراض النساء والتوليد
تاريخ الإجازة
1/1/2021
مكان الإجازة
جامعة بنها - كلية طب بشري - النساء والتوليد
الفهرس
Only 14 pages are availabe for public view

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from 86

Abstract

Labor is induced in 1 of 5 births, induction of labor for maternal reasons (e.g., preeclampsia, cardiac or renal disease), fetal reasons (e.g., intrauterine growth restriction) or a combination (e.g., poorly controlled diabetes, preterm rupture of the membranes or post-term pregnancy.
Induction of labor artificially ripens the cervix and initiates uterine contractions in women who are not already in labor, leading to progressive dilation of the cervix to achieve vaginal birth of a baby at any gestation beyond the legal definition of fetal viability.
The ability to predict the duration of induced labor is very important in the management of delivery units as it helps to avoid situations where there are too many simultaneous deliveries for the staff available. Cervical conditions determine the success of labor induction, but several studies have shown that the Bishop score has a poor predictive value for the result of induction.
Bishop score is the most commonly used method for the evaluation of cervix and successful delivery, but it is not a good method in predicting birth outcomes since its sensitivity is23–64%, Therefore, more sensitive selection criteria are needed with regard to induction of labor.
Fetal fibronectin (fFN) is a glycoprotein present in the amniotic fluid and in the areas between the decidua and the chorion and involved in the adhesion of cells present in the extracellular matrix of decidua basalis, adjacent to the intervillous space. It is synthesized by the trophoblast and permits adhesion between the blastocyst and the endometrium and between the chorion and the decidua. When delivery is imminent, fFN enters into cervical and vaginal secretions and therefore may be detected. fFN was initially reported as an indicator for premature delivery and can be used as a complementary test to confirm the clinical diagnosis of premature rupture of fetal membranes.
Recently a correlation between (fFN) presence and successful labor induction has also been found.
The aim of this work was to assess fetal fibronectin as a new tool for successful induction of labor in woman undergoing induction of labor in Benha Teaching Hospital and Benha University Hospital.
100 women undergoing labor induction in the 3rd trimester of pregnancy among those attended antenatal clinic of Benha University Hospital and Benha Teaching Hospital were studied.
This study showed that:
According to indication of induction, post-term pregnancy was the most frequently encountered reason for induction.
Induction was successful in 72% of the study subjects, while 28% of the mothers experienced failed induction.
There was statistically significant association between fetal fibronectin to the prediction of successful labor induction. A positive fibronectin assay had a sensitivity, specificity, positive predictive value, and negative predictive value of 90.3%, 57.2%, 84.4%, and 69.5%, respectively, for prediction of the induction success.
Failed induction were more likely in women with decreased Bishop Score.