الفهرس 
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Abstract
Summary
O
ral mucositis is the most common adverse effect of cytotoxic cancer therapy. It is an important cause of morbidity in cancer patients it may limit patient’s ability to tolerate and thus interrupting cancer chemotherapy treatment protocol. An effective therapy might be expected to reduce symptoms of mucositis and its duration and thus improve the patient’s nutritional status and quality of life.
Currently no intervention that is completely successful in prevention or treatment for this condition.
We have investigated the effectiveness of vitamin E compared with another antioxidant EPO in the resolution of mucosal lesions arising from the administration of chemotherapeutic agents to cancer patients.
The present study included 90 cancer patients suffering from acute lymphoblastic leukemia ALL, Non Hodgkins Lymphoma NHL, or Osteosarcoma OS.
All patients received Methotrexate as a common member of various chemotherapeutic drugs.
All patients suffering from oral mucositis were divided into three groups, group A (Vitamin E), group B (EPO), and group C (corn oil).
Our results suggest that topical administration of vitamin E may be effective therapy for chemotherapy-induced mucositis. While Evening Prim Rose oil was found to be no more effective than the placebo. Confirmatory studies with larger number of patients need to be done to verify this initial preliminary finding.
Records of plasmatic concentration of VE for subjects would have been important for confirming that effectiveness of VE is not due to significant intestinal absorption.