الفهرس 
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Abstract
PCOS which is a common endocrine disorder occurs in more than 10%
of women of reproductive age and is associated with increased prevalence of
cardiovascular risk factors (i.e., vascular endothelial dysfunction, insulin
resistance, hypertension, and dyslipidaemia).
Polycystic ovary syndrome (PCOS) is a complex and heterogeneous
disorder. Studying the mechanisms for the complex pathogenesis of PCOS
requires animal models with endocrine, reproductive, and metabolic
features of the syndrome.
Rat PCOS model induced by letrozole, a nonsteroidal aromatase
inhibitor, which blocks the conversion of androgens to estrogen.
Letrozole (LET) treatment of adult rats induced acyclicity or irregular
estrous cycles and anovulation, with ovaries exhibiting many large
follicular cysts and either reduced numbers or no corpora lutea. Vitamin D
supplementation may exert positive effects on PCO.
Aim:
This study aimed at studying the effect of vitamin D on letrozoleinduced
PCOS in female rats and whether there is a relationship between
vitamin D deficiency and pathophysiology of PCO.
Material and methods:
The study was conducted on 40 non-pregnant Wistar rats which
were divided into four groups: group I control (received 1 ml of 1%aqueous solution of (CMC)/day orally), group II letrozole-induced PCOS
group (received letrozole 200 μg/day orally), group III vitamin D-treated
group (received vitamin D 1000 IU/kg/day), group IV letrozole and
vitamin D treated group (received letrozole and vitamin D as group II and
group III for 90 days. BMI, ovarian weight, serum vitamin D, biochemical
metabolic and oxidative stress markers were evaluated, ovarian
tissues glutathione, malondialdehyde levels and caspase-3 activity were
measured. Histopathological examination of the ovary and coronary
artery were done.